World Class Histology

2009-08-28T10:30:00.000-07:00

UltraLight Immersion Oil
This breakthrough immersion oil provides clarity like you've never seen! The index of refraction is managed to provide you with the best view. See what you've been missing. The view in your microscope has never been so vivid and clear as with the new oil on your slides.

The set includes a classy holder and an optimum pen for the precise oil application. Visit

http://www.bi-biomics.com/ for more information.

2009-08-26T09:00:00.000-07:00

This is a high resolution light microscopy image. The tissue was processed using Ultralight Histology from Bi-Biomics - providing greatly improved detail. This is an image of a human ova in transition phase to a follicular structure. The image is at 600X. Click on the image for a full size view!

2009-08-05T07:56:00.000-07:00

Discovery: New Protein Secretory System in the Colon
New protein discovery gives chronic diarrhea patients hope. Many have been told it is all in their head, but this new research target may lead to help. Functional indicators and patient correlation are reasons for optimism.

PRLog (Press Release) – Aug 04, 2009 – Bi-Biomics announces the discovery of a new biological system in the gastrointestinal (GI) tract! Using UltraLight Histology to process colon biopsy samples the system was detected and studied at 1600X in light microscopy. It is a secretory system associated with the mucous in goblet cells in the colon. For one hundred years this has been known as inspissated mucous – that is – dried out mucous. It has been accepted without question until now.

The ultrastructure and fine details were uniquely available in light microscopy with the UltraLight system. This high end, low cost method was used to identify actual secretory features of this system on gastrointestinal biopsies. The next step was to identify the proteomics of the system.

Material was outsourced to Expression Pathology in Maryland for laser capture. The resulting material was forwarded to the Mayo Clinic Proteomics Laboratory. The samples were subjected to GC-MS/MS (gas chromatographic and mass spectral analysis). The result was a gold-mine. What was once only thought of as inspissated mucous actually turns out to be a significant secretion of proteins.

The proteins are predominantly identified as Cytokeratin I and Cytokeratin II in equal proportions. The secretion gives quantitative information that suggests approximately 4-6 grams of these cytokeratins are exported daily accompanying the glycoprotein of mucous. There were other proteins identified in much smaller amounts, giving the indication that this system is a deliberate protein excretion system.

The clinical significance was indicated early on in this discovery. It was first noted to be absent in a significant number of patients with a history of chronic diarrhea. While the family of cytokeratins is known to react with a host of different proteins, the function of this system is not yet fully known. It is hypothesized that it plays a role in stabilizing the boundary mucous layer lining the colon.

Bi-Biomics is searching for interested collaborators in the next step identifying clinical significance. This may give hope to the vast population that suffers from chronic diarrhea. If the functionality and correlation to GI illnesses can be worked out, the patients will know it is not “all in their head.”

Bi-Biomics is a life science discovery company from Nampa, Idaho. Our histology solutions have been in clinical practice for over 15 years. Now they can be yours to make a difference in the lives of your patients. For more information on the secretion system visit Bi-Biomics on the web at http://www.bi-biomics.com.

2009-06-29T04:06:00.000-07:00

Breakthrough: UltraLight Histology from Bi-Biomics

World-Class Histology that improves pathology diagnosis through better quality. Improved protein preservation and 100X better image detail make slides easier to read and diagnosis more accurate. Research was never so enjoyable as with UltraLight.

Jun 28, 2009 – Bi-Biomics unveils a ground breaking histology platform: UltraLight Histology. UltraLight Histology is a full solution lineup of histology reagents, protocols and cryostat tools that puts the clinical pathologist and the researcher at the forefront of personalized medicine.

Our world-class histology makes diagnosis easier and more accurate because the slides are easier to read. Research discoveries are more available than ever. UltraLight Histology is scientifically proven to have better protein preservation and 100 times better image quality. UltraLight Histology provides platinum quality tissue for the full range of pathology needs.

While the industry strives for standardization, UltraLight Histology is the answer. The balanced reagents and protocol are the premier option for all specimen types. “The last breast tissue slides you sent back were perfect! We used an H&E image on our AACR poster to show migrating cells and the loss of basement membrane. It made a very convincing picture and I told everyone at my poster about Bi-Biomics and the exquisite detail from your processing methods" stated Virginia Espina from George Mason University, Center for Applied Proteomics and Molecular Medicine.

The UltraLight Histology products are formalin based, so the immunohistochemistry (IHC) work pathologists are used to will be a smooth transition. Traditional methods based on 10% neutral buffered formalin have presented too many challenges that compromise the tissue and its proteins structure. These critical areas have been ignored for too long. UltraLight Histology is a result of over 600 experiments that provides world-class tissue detail and protein preservation.

UltraLight Histology solutions are available from our U.S. distributor, Pacific Southwest Lab Equipment; contact them at 866-429-0618 or on the web at http://www.psl-equip.com/ultralight.

Bi-Biomics is a life science discovery company from Nampa, Idaho. Our histology solutions have been in practice for over 15 years. Now they can be yours and can make a difference in the lives of your patients. Find more on Bi-Biomics at http://www.bi-biomics.com.

Super Kidney Biopsies

2009-06-23T10:31:00.000-07:00

Grayscale ~2000X. Arrows point to foot processes.

PAS stain 1200X.

Connective tissue stain 1600X. Note bright blue basement membrane.

All samples processed in UltraLight Histology.